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    • Shock Wave Therapy for Acute and Chronic Soft Tissue Wounds

    Shock Wave Therapy for Acute and Chronic Soft Tissue Wounds

    Title: Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study Authors: Wolfgang Schaden , Richard Thiele, Christine Kölpl, Michael Pusch, Aviram Nissan, Christopher E Attinger, Mary E Maniscalco-Theberge, George E Peoples, Eric A Elster, Alexander Stojadinovic...
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    Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

    Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

        Background aims As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for native Schwann cells for in vitro testing and/or reimplantation. Extracorporeal shockwave treatment (ESWT) is an emergent technology in the field of...
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    Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

    Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

    (​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria, 3 University Hospital for Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria,...
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    Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

    Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

    Abstract—Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation modulatory effects were described. However, the mechanism remains largely unknown. We hypothesized that SWT modulates inflammation via toll-like receptor 3 (TLR3) through the release of...
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    Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

    Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

    Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in ischemic tissue by modulation of early inflammatory response via Toll-like receptor (TLR)...
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    Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

    Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

    The current ‘‘gold standard’’ for treatment of chronic fracture nonunion in the metaphyseal-diaphyseal region of the fifth metatarsal is intramedullary screw fixation. Complications with this procedure, however, are not uncommon. Shock wave therapy can be an effective treatment for fracture...
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    ​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

    ​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

    Tibial non-unions are common cause of demanding revision surgeries and are associated with a significant impact on patients’ quality of life and health care costs. Extracorporeal shockwave therapy (ESWT) has been shown to improve osseous healing in vitro and in...
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    Shock Wave Therapy and Fracture Healing: A Bayesian Prediction Model

    Shock Wave Therapy and Fracture Healing: A Bayesian Prediction Model

    Title of study: Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions Authors: Alexander Stojadinovic, MD, Benjamin Kyle Potter, MD, John Eberhardt, BA, Scott B. Shawen, MD, Romney C. Andersen, MD, Jonathan A. Forsberg, MD, Clay Shwery,...
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    Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

    Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

    Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3). The antimicrobial peptide LL37 gets released by mechanical stress and is known to form complexes with nucleic acids thus activating Toll-like receptors. We...
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    Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

    Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

    Background Mechanical stimulation of acute ischemic myocardium by shock wave therapy (SWT) is known to improve cardiac function by induction of angiogenesis. However, SWT in chronic heart failure is poorly understood. We aimed to study whether mechanical stimulation upon SWT improves heart function in...
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    Shockwave Therapy Reduces Calcification of Decellularized Aortic Xenografts in Mice

    Shockwave Therapy Reduces Calcification of Decellularized Aortic Xenografts in Mice

    Title of study: Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice Authors: Can Tepeköylü, Daniela Lobenwein, Stefan Blunder, Radoslaw Kozaryn, Marion Dietl, Paul Ritschl, Elisabeth J Pechriggl, Michael J F...
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    Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

    Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

    Aims Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for the treatment of ischaemic heart or lim disease. Despite promising results in preclinical and clinical trials, the exact mechanism of action remains unknown. Toll-like...
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    Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

    Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

    Shock waves have been shown to induce recruitment of intravenously injected endothelial progenitor cells to ischemic hind limbs in rats. We hypothesized that shock wave treatment as sole therapy would induce angiogenesis in this ischemia model and would lead to...
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    Accelerated Healing of 2nd-Degree Burns with Shockwave Therapy

    Accelerated Healing of 2nd-Degree Burns with Shockwave Therapy

    Title: Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy Authors: Christian Ottomann, MD,∗ Alexander Stojadinovic, MD, FACS, Philip T. Lavin, PhD, Francis H. Gannon, MD, Michael H. Heggeness, MD, Richard...
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    Effects of Low-Energy Shock Waves on Oral Bacteria

    Effects of Low-Energy Shock Waves on Oral Bacteria

    Title: Effects of low-energy shock waves on oral bacteria Authors: K F Novak, M Govindaswami, J L Ebersole, W Schaden, N House, M J Novak Low-energy shock wave therapy (ESWT) has been found to be effective in promoting wound healing...
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    The Influence of Shockwave Therapy on Orthodontic Tooth Movement Induced in the Rat

    The Influence of Shockwave Therapy on Orthodontic Tooth Movement Induced in the Rat

    The application of orthodontic force evokes an inflammatory reaction resulting in tooth movement. Shockwave therapy might have an effect on both inflammatory and periodonal ligament cytokine profiles. Our aim was to evaluate the fluctuations of different inflammatory cytokines after orthodontic...
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    Shockwave Therapy Enhances Orthodontic Treatment Outcomes

    Shockwave Therapy Enhances Orthodontic Treatment Outcomes

    Title of Study: Periodontal cytokines profile under orthodontic force and extracorporeal shock wave stimuli in a rat model Authors: H. Hazan-Molina, A. Z. Reznick, H. Kaufman, D. Aizenbud Extracorporeal shock wave therapy (ESWT) is recognized for its healing stimulation in...
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    Shockwave Therapy No Effect on Pulpal Blood Flow in Orthodontic Patients, Study Shows

    Shockwave Therapy No Effect on Pulpal Blood Flow in Orthodontic Patients, Study Shows

    Title of study: Effect of extracorporeal shockwave therapy (ESWT) on pulpal blood flow after orthodontic treatment: a randomized clinical trial Authors: Frank Falkensammer, Wolfgang Schaden, Christoph Krall, Josef Freudenthaler, Hans-Peter Bantleon Extracorporeal Shockwave Therapy (ESWT) is a non-invasive treatment that...
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    Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

    Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

    This RCT investigated the effect of non-invasive extracorporeal shockwaves on tooth mobility in orthodontic patients after active treatment. Click here to read more.
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    Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

    Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

    Accelerated tooth movement has been a topic of interest for orthodontic research recently. Surgically facilitated orthodontic treatment has been shown to be an effective approach to accelerate tooth movement; however, it remains invasive, requires additional surgery, and may increase post-operative...
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    Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

    Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

    Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate lymphangiogenesis in vivo. The aim of this study was to investigate in vitro shockwave treatment (IVSWT) effects on lymphatic endothelial cell (LEC) behavior and lymphangiogenesis....
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    Shock waves induce angiogenesis via exosome release

    Shock waves induce angiogenesis via exosome release

    Shock waves induce angiogenesis via exosome release Graber M, Pölzl L, Lobenwein D, Graber M, Blumer M, Kirchmair E, Kirchmair R, Paulus P, Davidson S, Grimm M, Tepeköylü C, Holfeld J. Background: The mechanism of mechanotransduction of shock wave therapy...
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    Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model

    Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model

    To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress urinary incontinence (SUI) in a vaginal balloon dilation (VBD) rat model. Click here to read more.
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    Shock Wave Therapy Improves Erectile Dysfunction in Patients

    Shock Wave Therapy Improves Erectile Dysfunction in Patients

    Title of study: Effectiveness of Shock Wave Therapy: Implementation of a Soft Wide Focus Applicator in Patients with Erectile Dysfunction Authors: José Pablo Saffon, Juan Manuel Martínez, Carolina Sandoval, Héctor A. Corredor A new study published in the journal Actas...
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    Shockwave Therapy for Diabetic Erectile Function – A Study

    Shockwave Therapy for Diabetic Erectile Function – A Study

    Title: Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model Authors: Xuefeng Qiu, Guiting Lin, Zhongcheng Xin, Ludovic Ferretti, Haiyang Zhang, Tom F Lue, Ching-Shwun Lin Low-energy shockwave therapy (LESWT) has shown promise...
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    Prophylactic Low-Energy Shock Wave Therapy Improves Wound Healing After Vein Harvesting for Coronary Artery Bypass Graft Surgery: A Prospective, Randomized Trial

    Prophylactic Low-Energy Shock Wave Therapy Improves Wound Healing After Vein Harvesting for Coronary Artery Bypass Graft Surgery: A Prospective, Randomized Trial

    Wound healing disorders after vein harvesting for coronary artery bypass graft surgery increase morbidity and lower patient satisfaction. Low-energy shock wave therapy (SWT) reportedly improves healing of diabetic and vascular ulcers by overexpression of vascular endothelial growth fractor and downregulation...
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    Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

    Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

    This study investigated the plasma protein expression in the extracorporeal shock wave therapy group and diabetic controls using proteomic study. A dorsal skin defect (6 × 5 cm) in a streptozotocin-induced diabetic Wistar rat model was used. Diabetic rats receiving...
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    Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

    Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

    Shockwave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the beneficial effects of shockwaves have not yet been fully revealed. Since cell proliferation is a major requirement in the wound healing cascade, we used in...
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    Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

    Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

    Anna M Larking, Sophie Duport Institute of Neuropalliative Rehabilitation, Royal Hospital for Neuro-disability, Michael Clinton Department of Management, King’s College, Mary Hardy Practice Development, Royal Hospital for Neurodisability and Keith Andrews Institute of Neuropalliative Rehabilitation, Royal Hospital for Neuro-disability, London, UK...
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    MTS Spark Wave Publications – Science Telegram

    MTS Spark Wave Publications – Science Telegram

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    MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

    MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

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    MTS Science White Paper – Softwave – Pain Therapy

    MTS Science White Paper – Softwave – Pain Therapy

      MTS Science White Paper © SoftWave ™ - Pain Therapy Research Assessment & Scientific Guide Author: Sarah Engel (M.Sc.)                                         ...
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    Biomechanical Improvement by Shockwave After Rotator Cuff Repair

    Biomechanical Improvement by Shockwave After Rotator Cuff Repair

    Title: Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears Authors: Xaver Feichtinger, Xavier Monforte, Claudia Keibl, David Hercher, Jakob Schanda, Andreas H Teuschl, Christian Muschitz, Heinz Redl, Christian Fialka, Rainer Mittermayr A...
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    Treatment of scaphoid waist nonunion

    Treatment of scaphoid waist nonunion

    Introduction: Scaphoid nonunion remains challenging for hand surgeons. Several treatment options are available such as: non-vascularized or vascularized bone grafting, with or without additional stabilization. In the last few decades, extracorporeal shockwave therapy (ESWT) has become an established procedure for treating...
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    Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

    Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

    Skin grafting is one of the most common treatment options for permanent replacement of lost skin. Successful healing and engraftment is destined by degree of ischemia, angiogenesis and inflammation in the graft tissue. Exrtacorporeal shockwave therapy (ESWT) has been shown to have beneficial effects in soft tissue wounds through increase in...
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    Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

    Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

    Shock wave therapy (SWT) has been shown to induce angiogenesis in ischaemic muscle. However, the mechanism of action remains unknown. Macrophages are crucial for angiogenic responses after ischaemic injury. The M2 macrophage subset enables tissue repair and induces angiogenesis. It...
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    Single Shockwave Treatment Shows Promise in Relieving Muscle Soreness

    Single Shockwave Treatment Shows Promise in Relieving Muscle Soreness

    Title: Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial Authors: Johannes Fleckenstein, Mara Friton, Heiko Himmelreich, Winfried Banzer A study investigated the effects...
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    Optimization of screw fixation in rat bone with extracorporeal shock waves

    Optimization of screw fixation in rat bone with extracorporeal shock waves

      Screw fixation in osteoporotic patients is becoming an increasing problem in orthopaedic surgery as deterioration of cortical and cancellous bone hamper biomechanical stability and screw fixation. This might result in delayed weight-bearing or failure of instrumentation. We hypothesized that...
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    Enhancing Adipose Cells with Low-Energy Shockwave Therapy

    Enhancing Adipose Cells with Low-Energy Shockwave Therapy

    Title of Study: Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy Authors: Ellen Priglinger, Christina M A P Schuh, Carolin Steffenhagen, Christoph Wurzer, Julia Maier, Sylvia Nuernberger, Wolfgang Holnthoner, Christiane Fuchs, Susanne Suessner, Dominik Runzler, Heinz Redl,...
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    Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

    Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

        Background: In this study we examined the effects of two different repeated Extracorporeal Shock Waves (ESW) on the consolidation period of the distraction osteogenesis (DO) of the rabbit mandible using stereological, radiological and immunohistochemical methods. Material and methods: DO...
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    The Concept of Spark Wave Therapy (Swt) Assisted Penile Augmentation

    The Concept of Spark Wave Therapy (Swt) Assisted Penile Augmentation

    Spark Wave Therapy(SWT) works on the basis of Angiogenesis and tissue regeneration. The therapeutic approach involves usage of penile traction devices, hydropump in combination with SWT to induce penile tissue hyperplasia in a controlled manner which can be considered as...
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    Shockwave Therapy & Lymphatic Drainage for Chronic Ulcers Treatment

    Shockwave Therapy & Lymphatic Drainage for Chronic Ulcers Treatment

    Title: The Role of Extracorporeal Shock Wave Therapy and Manual Lymphatic Drainage in Chronic Ulcers Treatment Authors: Raoul Saggini, A Saggini, Sm Carmignano, T Palermo, G Barassi, Mg Onesti, Rg Bellomo and N Scuderi Chronic wounds, such as diabetic foot...
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    Extracorporeal Shock Wave Therapy for Retracting Scars of the Hands

    Extracorporeal Shock Wave Therapy for Retracting Scars of the Hands

    Title: Extracorporeal Shock Wave Therapy: An Emerging Treatment Modality for Retracting Scars of the Hands Authors: Raoul Saggini, Andrea Saggini, Anna Maria Spagnoli, Ira Dodaj, Emanuele Cigna, Michele Maruccia, Giuseppe Soda, Rosa Grazia Bellomo, Nicolò Scuderi Abnormal and prolonged scarring...
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    Boosting Cardiac Performance: Epicardial Shockwave Therapy in Ischaemic Models

    Boosting Cardiac Performance: Epicardial Shockwave Therapy in Ischaemic Models

    Title: Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease Authors: Johannes Holfeld, Daniel Zimpfer, Karin Albrecht-Schgoer, Alexander Stojadinovic, Patrick Paulus, Julia Dumfarth, Anita Thomas, Daniela Lobenwein, Can Tepeköylü, Raphael Rosenhek, Wolfgang Schaden, Rudolf Kirchmair,...
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    Lithotripter outcomes in a community practice setting

    Lithotripter outcomes in a community practice setting

    Purpose: We assessed patient outcomes using 2 widely different contemporary lithotripters. Materials and methods: We performed a consecutive case series study of 355 patients in a large private practice group using a Modulith® SLX electromagnetic lithotripter in 200 patients and a...
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    Shockwave Therapy Alters Macrophage Biology for Tissue Regeneration

    Shockwave Therapy Alters Macrophage Biology for Tissue Regeneration

    Title of study: Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling Authors: Naths Grazia Sukubo, Elisabetta Tibalt, Stefano Respizzi, Massimo Locati, M Cristina d'Agostino Shockwave therapy is a non-surgical treatment widely used to treat...
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    In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

    In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

    AbstractBackground: The objective of the presented study is to investigate in vitro effects of low energy extracorporeal shockwave therapy (ESWT) on the keratinocytes and their metabolic and proliferative properties for their therapeutic applications.Materials: Primary culture of keratinocytes was isolated from...
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    Effectiveness of Extracorporeal Shock Wave Lithotripsy to treat Dystrophic Calcinosis Cutis

    Effectiveness of Extracorporeal Shock Wave Lithotripsy to treat Dystrophic Calcinosis Cutis

    Delgado-Marquez et al.Actas Dermosifiliogr. 2015 Mar;106(2):140-3. doi: 10.1016/j.ad.2014.06.006.  Click here to read more.
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    In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived cells

    In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived cells

    Background aims: Adipose-derived progenitor/cells (ASCs) are discussed as a promising candidate for various tissue engineering approaches. However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity...
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    Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

    Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

    Objectives: This randomized clinical trial investigated the effect of extracorporeal shock waves on the amount of orthodontic tooth movement and periodontal parameters. Material and methods: Twenty-six adult orthodontic patients participated in this clinical trial; all of them receiving lower second molar...
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    Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults

    Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults

    Introduction: In this randomized, placebo-controlled clinical trial, we investigated the effect of noninvasive extracorporeal shock waves on the stability of temporary anchorage devices (TADs) under orthodontic loading. Methods: Thirty adult orthodontic patients of the Bernhard Gottlieb University Clinic in Vienna, Austria,...
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    Evaluation of LithoGold LG-380 Lithotripter and Renal Injury Assessment

    Evaluation of LithoGold LG-380 Lithotripter and Renal Injury Assessment

    Title: Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model Authors: Yuri A Pishchalnikov, James A McAteer, James C Williams Jr, Bret A Connors, Rajash K Handa, James E Lingeman,...
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    Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

    Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

    Unfocused extracorporeal shock waves (UESW) have been shown to have an anabolic effect on bone mass. Therefore we investigated the effects of UESW on bone in osteoporotic rats with and without anti-resorptive treatment. Twenty-week-old rats were ovariectomized (n = 27)....
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    Shockwave Therapy May Help Regulate Cytokine Concentration in Orthodontics

    Shockwave Therapy May Help Regulate Cytokine Concentration in Orthodontics

    Title of study: Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy Authors: Hagai Hazan-Molina, Abraham Z Reznick, Hanna Kaufman, Dror Aizenbud This study aimed to investigate the effects of...
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    Benefits of Shockwave Therapy for Nerve Regeneration

    Benefits of Shockwave Therapy for Nerve Regeneration

    Title of Study:  Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat Authors: Thomas Hausner, Krisztián Pajer, Gabriel Halat, Rudolf Hopf, Robert Schmidhammer, Heinz Redl, Antal Nógrádi This study explores how de-focused low-energy extracorporeal...
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    Shockwave Therapy Promotes Blood Vessel Formation in Human Cells

    Shockwave Therapy Promotes Blood Vessel Formation in Human Cells

    Title of study: Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1) Authors: V Sansone, M C D' Agostino, C Bonora, F Sizzano, L De Girolamo, P Romeo This study investigated the...
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    Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

    Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

    For almost 30 years, extracorporeal shock wave therapy has been clinically implemented as an effective treatment to disintegrate urinary stones. This technology has also emerged as an effective noninvasive treatment modality for several orthopedic and traumatic indications including problematic soft...
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    Macrophage migration induces angiogenesis in ischemic myocardium after direct epicardial shock wave treatment

    Macrophage migration induces angiogenesis in ischemic myocardium after direct epicardial shock wave treatment

      Introduction: Shock wave therapy (SWT) reportedly improves ventricular function in ischemic myocardium. The induction of a vessel forming effect is obvious. We aimed to proof the mechanism of angiogenesis by direct epicardial SWT in a rat model of ischemic heart...
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    Unfocused extracorporeal shock waves induce anabolic effects in rat bone

    Unfocused extracorporeal shock waves induce anabolic effects in rat bone

    Background: Extracorporeal shock waves are known to stimulate the differentiation of mesenchymal cells toward osteoprogenitors and induce the expression of osteogenic-related growth hormones. The aim of this study was to investigate if and how extracorporeal shock waves affected new bone formation,...
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    Improving Urinary Stone Treatment: An Interview with Dr. Lingeman

    Improving Urinary Stone Treatment: An Interview with Dr. Lingeman

    Title: Better Lithotripsy On the Horizon: Interview with James Lingeman, MD Author: Delicia Honen Yard A leading authority on kidney stone disease, James E. Lingeman, MD, of Indiana University Health, updates Renal & Urology News on the state of urinary...
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    Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

    Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

    Objective: To assess the time-dependent treatment effects of extracorporeal shock wave therapy (ESWT) in a standard rodent ischemic epigastric flap model. Background: ESWT has been shown to accelerate tissue repair in acute and chronic wounds and improve graft survival, but the mechanism...
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    Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

    Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

    Die extrakorporale Stoßwellentherapie (ESWT) stellt eine potente Alternative in der Behandlung von Knochenpathologien wie Pseudarthrosen und avaskulären Hüftkopfnekrosen dar. Klinisch beobachtete Therapieerfolge wurden bereits in experimentellen Versuchen bestätigt und der Wirkungsmechanismus zunehmend aufgeklärt – es geht von einer ursprünglich mechanischen...
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    Shockwave Therapy Boosts Wound Healing Genes in Diabetic Mice

    Shockwave Therapy Boosts Wound Healing Genes in Diabetic Mice

    Title of study: Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: effects of extracorporeal shock wave therapy Authors: Stephen R Zins, Mihret F Amare, Douglas K Tadaki, Eric A Elster, Thomas A Davis...
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    Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

    Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

    Background: Extracorporeal shock wave therapy may enhance revascularization and repair of healing soft tissue. Methods: Between January 2006, and September 2007, 28 patients with acute traumatic wounds and burns requiring skin grafting were randomly assigned in a 1:1 fashion to receive...
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    The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

    The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

    Possible effects of comorbidities and of different wound etiologies on the success of extracorporeal shock wave therapy (ESWT) of chronic soft tissue wounds were investigated. From September 2003 until February 2007, 282 patients, being previously treated unsuccessfully were enrolled. Treatment...
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    Shockwave Therapy Improves Heart Function in Ischemic Heart Failure

    Shockwave Therapy Improves Heart Function in Ischemic Heart Failure

    Title of study: Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure Authors: Daniel Zimpfer, Seyedhossein Aharinejad, Johannes Holfeld, Anita Thomas, Julia Dumfarth, Raphael Rosenhek, Martin Czerny, Wolfgang Schaden, Mathias Gmeiner, Ernst Wolner, Michael...
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    Shockwave Therapy Promotes Healing and Reduces Inflammation in Severe Burn Wounds

    Shockwave Therapy Promotes Healing and Reduces Inflammation in Severe Burn Wounds

    Title: Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury Authors: Thomas A Davis, Alexander Stojadinovic, Khairul Anam, Mihret Amare, Shruti Naik, George E Peoples, Douglas Tadaki, Eric A Elster DOI: 10.1111/j.1742-481X.2008.00540.x Summary: ...
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    Unfocused Shock Wave Therapy Shows Promise for Osteoporosis Treatment

    Unfocused Shock Wave Therapy Shows Promise for Osteoporosis Treatment

    Title: Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis Authors: Olav P van der Jagt, Jacqueline C van der Linden, Wolfgang Schaden, Hans T van Schie, Tom M Piscaer, Jan A N Verhaar, Harrie Weinans, Jan H Waarsing...
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    Shockwave Therapy Enhances Skin Graft Revascularization in Mice

    Shockwave Therapy Enhances Skin Graft Revascularization in Mice

    Tile of study: Angiogenic response to extracorporeal shock wave treatment in murine skin isografts Authors: Alexander Stojadinovic, Eric A Elster, Khairul Anam, Douglas Tadaki, Mihret Amare, Stephen Zins, Thomas A Davis Skin grafts are commonly used to cover open wounds...
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    Extracorporeal shockwave therapy induces alveolar bone regeneration

    Extracorporeal shockwave therapy induces alveolar bone regeneration

    Abstract   Periodontal inflammation with alveolar bone resorption is a hallmark of periodontitis. We hypothesized that extracorporeal shock wave therapy (ESWT) could promote the regeneration of alveolar bone following Porphyromonas gingivalis-induced periodontitis in rats. Rats were infected with P. gingivalis...
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    Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

    Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

    Introduction:Extracorporeal Shockwave (ESW) therapy has shown to be effective in the treatment of non-unions and can enhance healing of fresh fractures(1). Enhanced proliferation and differentiation of osteoprogenitor cells have been shown in rats after a single ESW treatment(2). These studies...
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    Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

    Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

          Introduction: Electro-Hydraulic Extracorporeal Shockwave generation results a shot-varying non-linear sound-fields which are not yet properly characterized. Material and Method: We have utilized a non-linear wave-propagation simulation in conjunction with experimental spark-gap measurements to predict statistical variations of...
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    Unfocused Low Intensity Extracorporeal Shock Wave Therapy

    Unfocused Low Intensity Extracorporeal Shock Wave Therapy

          ISMST Congress 2019 Beijing, China Abstract No. P45 B. Sharpe M.D., Georgia Urology, USA            First Report for Unfocused Li-eswt for Nocturia and Erectile Dysfunction. Introduction and Objective: Nearly 350 Shockwave Therapy (SWT)...
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    Shockwave Treatment Improves Chronic Pelvic Pain Syndrome in Men

    Shockwave Treatment Improves Chronic Pelvic Pain Syndrome in Men

    Title of study: PD32-03 Case Series of Low Intensity Shock Wave Therapy for Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome Authors: Daniel Shoskes and Brandon Mooney Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a complex and difficult-to-treat condition affecting men....
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    Accelerating Nerve Regeneration: The Impact of ESWT on Schwann Cells

    Accelerating Nerve Regeneration: The Impact of ESWT on Schwann Cells

    Title: ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration Authors: David Hercher, Christina M.A.P Schuh, Michaela Stainer, Rudolf Hopf, James Ferguson, Dominik Rünzler, Heinz Redl, Antal Nógrádi, Thomas Hausner This study focused on the...
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    Case Series of Weekly Low Intensity Shockwave Therapy for Erectile Dysfunction

    Case Series of Weekly Low Intensity Shockwave Therapy for Erectile Dysfunction

        Background & Aim: Low Intensity Shock Wave (LiSW) has emerged as a therapy for vasculogenic erectile dysfunction (ED). Mechanism may be related to angiogenesis, release of growth factors and/or recruitment of cells. Several sham controlled studies have shown...
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    Investigating Molecular Mechanisms of Cardiac Shockwave Treatment

    Investigating Molecular Mechanisms of Cardiac Shockwave Treatment

    Title: Elucidating the molecular mechanisms underlying cardiac shock wave therapy Authors: Dorota Szwarc, Christiane Fuchs, Michaela Purtscher, Dominik Runzler Researchers Dorota Szwarc, Christiane Fuchs, Michaela Purtscher, and Dominik Runzler conducted a study to explore the molecular mechanisms underlying cardiac shockwave...
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    Shock wave treatment of muscle cells

    Shock wave treatment of muscle cells

    Introduction Shock waves have recently been exploited for treatment of skeletal muscle especially in the elderly as they can suffer from muscle waste resulting in a high socioeconomic burden. Material and Method Murine C2C12 & human C25 myoblasts and primary...
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    Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptoms in a first-in-man trial

    Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptoms in a first-in-man trial

    Introduction In pre-clinical and clinical studies SWT had a favorable effect on ischemic myocardium. We therefore hypothesized that SWT may have a beneficial effect on spinal cord ischemia. Material and Method Mice underwent aortic cross clamp surgery and received 500...
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    Shock wave therapy for osteoinduction

    Shock wave therapy for osteoinduction

    Introduction Bone substitutes can be used if human's capacity for bone regeneration is lacking. We think that shock waves (UESW) can improve bone ingrowth and angiogenesis. Material and Method Three different bone substitutes were implanted in a 6 mm femoral...
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    Efficacy of extracorporeal shockwave therapy (ESWT) for male chronic pelvic pain syndrome

    Efficacy of extracorporeal shockwave therapy (ESWT) for male chronic pelvic pain syndrome

        Introduction: Chronic Prostatitis/ Chronic Pelvic Pain Syndrome (CP/CPPS) according to NIH is genitourinary pain or discomfort lasting 3 or more months with undetectable uropathogenic bacteria. Material & Methods: Randomized, double blind, placebo controlled study has been conducted in...
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    Penile low-intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic erectile dysfunction since 2-10 years

    Penile low-intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic erectile dysfunction since 2-10 years

    Background: Several animal and human studies have evaluated the role of lowintensity extracorporeal shockwave therapy (LIST) in the management of multiple disorders such as chronic wounds, peripheral neuropathy and cardiac ischemic disease. LIST was reported to trigger a chain of...
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    Penile low intensity shock wave therapy

    Penile low intensity shock wave therapy

    European Congress of Andrology, Rotterdam 2016 Poster Session SD13   Background: Several animal and human studies have evaluated the role of low-intensity extracorporeal shockwave therapy (LIST) in the management of multiple disorders such as chronic wounds, peripheral neuropathy and cardiac...
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    Shock wave treatment for in vitro engineering applications

    Shock wave treatment for in vitro engineering applications

    Introduction: Recently, the cellular effects of shock wave treatment have been thoroughly studied using in vitro approaches. We already described intracellular pathways involved in the shock wave treatment effect using the in vitro shock wave treatment (IVSWT) water bath set-up...
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    The beneficial effects of in vitro shock wave treatment on cardiomyogenesis

    The beneficial effects of in vitro shock wave treatment on cardiomyogenesis

    Introduction: In the recent years, more and more evidence for the beneficial effect of shock waves for the treatment of cardiac diseases is arising. Myocardial infarction (MI) and other cardiac diseases are still the number one reason for death as...
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    Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

    Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

    Background: Low energy shock waves (SW) have been shown to induce angiogenesis in ischemic myocardium. The mechanism translating the physical stimulus to a biological signal is unknown. Toll-like receptor (TLR)-3 is activated by RNA binding. It plays a key role...
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    Shockwave Therapy Stimulates Angiogenesis to Treat Ischemic Heart Disease

    Shockwave Therapy Stimulates Angiogenesis to Treat Ischemic Heart Disease

    Title of study: Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy of ischemic muscle Author: Can Gollmann-Tepeköylü, Michael Graber, Daniela Lobenwein, E. Kirchmair, M. Grimm, Johannes Holfeld Shockwave therapy (SWT) is a promising treatment for ischemic...
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    In vitro extracorporeal shock wave treatment has beneficial effects on rat Schwann cell isolation and culture

    In vitro extracorporeal shock wave treatment has beneficial effects on rat Schwann cell isolation and culture

    Introduction: As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for native Schwann cells for in vitro testing and/or reimplantation. Extracorporeal shockwave treatment (ESWT) is an emergent technology in the field of regenerative medicine, which...
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    Shock wave therapy enhances neuronal sprouting and improves neuronal survival

    Shock wave therapy enhances neuronal sprouting and improves neuronal survival

    Shock wave therapy enhances neuronal sprouting and improves neuronal survival   Background: Shock wave therapy (SWT) has been shown to induce tissue regeneration and improve function in spinal cord ischemia via TLR3. Thereby, induction of angiogenesis and alteration of microglial...
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    Shock wave treatment reduces neuronal degeneration

    Shock wave treatment reduces neuronal degeneration

    Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia via a Toll-like receptor 3 dependent mechanism   OBJECTIVES: Paraplegia following spinal cord ischemia represents the most severe complication of aortic surgery. Shock wave treatment (SWT) was shown to induce...
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    The effect of shock waves on in vitro cartilage development in silk scaffolds

    The effect of shock waves on in vitro cartilage development in silk scaffolds

    The effect of shock waves on in vitro cartilage development in silk scaffolds 1.2 Dorota Szwarc¹,2, Christiane Fuchs12, Anna M. Weihs" Xavier Monforte Vila12, Dominik Hanetseder¹², Andreas H. Teuschl12, Dominik Rünzler¹.2 1 University of Applied Sciences Technikum Wien, Department of...
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    Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

    Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

      Objective: Shock wave therapy (SWT) has been shown to induce angiogenesis in ischemic muscle However, the mechanism of action remains unknown. Macrophages are crucial for angiogenic responses after ischemia. Proinflammatory M1 macrophages phagocytise necrotic tissue. M2 macrophages create a...
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    Shock wave application to cell cultures

    Shock wave application to cell cultures

      Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that shock waves do cause a biological stimulus to target cells or tissue without any subsequent damage. Therefore, in vitro experiments are of increasing interest. Various...
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