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Stem Cells Research

Doubts Over Heart Stem-Cell Therapy by Alison Abbott

Doubts Over Heart Stem-Cell Therapy by Alison Abbott

Title of article: Doubts over heart stem-cell therapy Author: Alison Abbott The idea that cells could be used to repair damaged heart tissue has been the subject of research for decades. In 2011, a team of researchers at the University...
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Cutaneous Wound Healing Accelerated by hiPSC-MSC Exosomes

Cutaneous Wound Healing Accelerated by hiPSC-MSC Exosomes

Title: Exosomes released from human induced pluripotent cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis Authors: Jieyuan Zhang, Junjie Guan, Xin Niu, Guowen Hu, Shangchun Guo , Qing Li , Zongping Xie , Changqing Zhang and...
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MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

Xi Ouyang , Xiaoyan Han , Zehong Chen, Jiafeng Fang, Xuna Huang and Hongbo Wei – This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model of cavernous nerve injury (CNI). Click here to...
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The Importance of Mechanical Signals in Regulating Cellular Behavior

The Importance of Mechanical Signals in Regulating Cellular Behavior

Title of study: Cellular Mechanotransduction: Putting All the Pieces Together Again Author: Donald E. Ingber This study delves into cellular mechanotransduction, which is the process by which cells convert mechanical signals into biochemical responses. Scientists have identified various mechanosensitive molecules...
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Mesenchymal cells: Myths and reality

Mesenchymal cells: Myths and reality

Mesenchymal cells (MSCs; also called mesenchymal stromal cells) have received much attention during the last two decades, at first because of their regeneration capacity and poor immunogenicity and, more recently, because of their proved immunomodulatory function. Click here to read...
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Shock Wave Therapy Promotes Angiogenesis via Toll-like Receptor 3

Shock Wave Therapy Promotes Angiogenesis via Toll-like Receptor 3

Title of study: Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle Authors: Johannes Holfeld, Can Tepeköylü, Christin Reissig, Daniela Lobenwein, Bertram Scheller, Elke Kirchmair, Radoslaw Kozaryn, Karin Albrecht-Schgoer, Christoph Krapf, Karin Zins, Anja Urbschat,...
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Scientific Reports – Gene transfection by shock waves

Scientific Reports – Gene transfection by shock waves

Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids into various cell lines through the process of sonoporation, a process that affects the permeation of cell membranes, which can be an effect of cavitation....
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Novel Approach to Obtain an Activated Fat Graph

Novel Approach to Obtain an Activated Fat Graph

One of the mainstays of facial rejuvenation strategies is volume restoration, which can be achieved by autologous fat grafting. In our novel approach, we treated the adipose tissue harvest site with extracorporeal shock wave therapy (ESWT) in order to improve...
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UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Platelet-rich plasma (PRP) and extracorporeal shockwave therapy (ESWT) are both used for the treatment of soft tissue injuries in horses. Clinically, the question has been raised whether these two therapies could be used in combination. The hypothesis of this study...
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Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

Mononuclear invasion of Langerhans islet and the ensuing insulitis triggers signal-transduction for the autoimmune mediated pancreatic beta-cell (b-cell) apoptosis that severely disrupts insulin production resulting in hyperglycemia associated with Type-1 diabetes (T1DM). Today extensive global research is being conducted to...
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​Shockwaves induce osteogenic differentiation of human mesenchymal cells through ATP release and activation of P2X7 receptors

​Shockwaves induce osteogenic differentiation of human mesenchymal cells through ATP release and activation of P2X7 receptors

Shockwave fractures treatment promotes bone healing of nonunion fractures. In this study, we investigated whether this effect could be due to adenosine 5’-triphosphate (ATP) release-induced differentiation of human mesenchymal cells (hMSCs) into osteoprogenitor cells. Cultured bone marrow-derived hMSCs were subjected...
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Shockwave Therapy Enhances Stem Cell Healing Potential

Shockwave Therapy Enhances Stem Cell Healing Potential

Title of study: Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells Authors: Frank Suhr, Yvonne Delhasse, Gerd Bungartz, Annette Schmidt, Kurt Pfannkuche, Wilhelm Bloch Human bone marrow stromal...
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Shockwave Therapy Boosts Equine Stem Cell Proliferation and Viability

Shockwave Therapy Boosts Equine Stem Cell Proliferation and Viability

Title of study: Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal cells in vitro Authors: O Raabe, K Shell, A Goessl, C Crispens, Y Delhasse, A Eva, G Scheiner-Bobis, S Wenisch, S Arnhold Researchers...
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Shockwave & Stem Cell Combo Improves Critical Limb Ischemia in Rats

Shockwave & Stem Cell Combo Improves Critical Limb Ischemia in Rats

Title of study: Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats Authors: Kuo-Ho Yeh, MD; Jiunn-Jye Sheu, MD; Yu-Chun Lin, PhD; Cheuk-Kwan Sun, MD, PhD; Li-Teh Chang, PhD;...
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Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

We tested whether shock wave (SW) offers additional benefits in improving left ventricular (LV) function after acute myocardial infarction (AMI) in rabbits receiving SW-treated autologous bone marrow-derived mononuclear cells (BMDMNCs) transplantation. Click here to read more.
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​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Ligament-to-bone and tendon-to-bone interfaces (entheses, osteotendinous junctions [OTJs]) serve to dissipate stress between soft tissue and bone. Surgical reconstruction of these interfaces is an issue of considerable importance as they are prone to injury and the integration of bone and...
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“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal cells

“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal cells

The stromal vascular fraction (SVF) is a heterogeneous cell population derived from the adipose tissue. There is still a lack of information concerning the characterization of the cell subpopulations constituting the SVF as well as its mesenchymal and haematopoietic potential....
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Shockwave Therapy Enhances Bone Cell Growth and Differentiation

Shockwave Therapy Enhances Bone Cell Growth and Differentiation

Title: Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-beta1 Authors: F. S. Wang, K. D. Yang, R. F. Chen, C. J. Wang, S. M. Sheen-Chen This study investigated the effects...
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miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous repair mechanisms in ischaemic heart disease is of particular interest. Recently, exosomes carrying angiogenic miRNAs have been described to improve heart function. However, it remains...
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Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It is currently accepted that the isolation, expansion and application of resident cardiac cells may hold therapeutic promise for the future. Recently, it has been demonstrated...
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Doubts over heart stem-cell therapy

Doubts over heart stem-cell therapy

The cells are then injected back into the patient, to help repair damaged tissue. Original claims that they differentiated into replacement cells have been rejected , and many clinicians now believe that the cells act by releasing molecules that cause...
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Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

(Alexandra Aicher, MD; Christopher Heeschen, MD; Ken-ichiro Sasaki, MD; Carmen Urbich, PhD; Andreas M. Zeiher, MD; Stefanie Dimmeler, PhD) – Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of...
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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

Background Mechanical stimulation of acute ischemic myocardium by shock wave therapy (SWT) is known to improve cardiac function by induction of angiogenesis. However, SWT in chronic heart failure is poorly understood. We aimed to study whether mechanical stimulation upon SWT improves heart function in...
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Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate lymphangiogenesis in vivo. The aim of this study was to investigate in vitro shockwave treatment (IVSWT) effects on lymphatic endothelial cell (LEC) behavior and lymphangiogenesis....
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Shock waves induce angiogenesis via exosome release

Shock waves induce angiogenesis via exosome release

Shock waves induce angiogenesis via exosome release Graber M, Pölzl L, Lobenwein D, Graber M, Blumer M, Kirchmair E, Kirchmair R, Paulus P, Davidson S, Grimm M, Tepeköylü C, Holfeld J. Background: The mechanism of mechanotransduction of shock wave therapy...
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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shockwave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the beneficial effects of shockwaves have not yet been fully revealed. Since cell proliferation is a major requirement in the wound healing cascade, we used in...
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Enhancing Adipose Cells with Low-Energy Shockwave Therapy

Enhancing Adipose Cells with Low-Energy Shockwave Therapy

Title of Study: Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy Authors: Ellen Priglinger, Christina M A P Schuh, Carolin Steffenhagen, Christoph Wurzer, Julia Maier, Sylvia Nuernberger, Wolfgang Holnthoner, Christiane Fuchs, Susanne Suessner, Dominik Runzler, Heinz Redl,...
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