Biologic Response

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases of energy. The best-known natural phenomenon is thunder following lightning. Another example is the “bang” an aircraft produces when it breaks the sound barrier. Both...

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of nonunion. In addition, it has been shown to have direct antibacterial effects. We evaluated fhESWT as an adjunct to conventional treatment in a clinically relevant...

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3). The antimicrobial peptide LL37 gets released by mechanical stress and is known to form complexes with nucleic acids thus activating Toll-like receptors. We sug- gested...

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases for its pro-angiogenic and anti-inflammatory effects. However, the molecular mechanisms translating tissue exposure to shock waves (SW) in a biological response with potential therapeutic activity...

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration. Click here to read more.

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Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications as urological lithotripsy, gained the field of musculo-skeletal diseases as Orthotripsy (mainly tendinopaties and bone regenerative disorders) and Regenerative Medicine as well. Click here to...

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the beneficial effects of shock waves have not yet been fully revealed. Because cell proliferation is a major requirement in the wound healing cascade, we...

Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth factor is crucial for the recruitment of...

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how important basic research findings on the cellular and sub-cellular level are for the future progress of shock wave therapy. In some very emerging fields better...

Title of study: Biological Mechanism of Musculoskeletal Shockwaves Authors: Ching-Jen Wang, MD (The Department of Orthopedic Surgery Chang Gung Memorial Hospital at Kaohsiung Taiwan), Feng-Sheng Wang, PhD (Medical Research Chang Gung Memorial Hospital at Kaohsiung Taiwan) and Kuender D. Yang,...

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        MANUAL    IVSWT Water Bath V2.0    Standardized Model for   In-Vitro Shock Wave Treatment (IVSWT)                Manual: IVSWT Water Bath V2.0 1 Introduction  by Johannes Holfeld, MD Innsbruck Medical University, Austria, October 2010 The number of in-vitro experiments in shock wave science increases continuously. This fact reflects  how  important  basic  research  findings  on  the  cellular  and  sub-cellular  level  are  for the future progress of shock wave therapy. In some very emerging fields better mechanistic understandings may be prerequisite for translation into clinical use or will at least support the application of already well established indications. Today’s  knowledge  of  shock  wave  effects  on  cell  cultures  includes  the  increase  of proliferation,  alteration  of  cell  membrane  receptors,  increase  and  acceleration  of  cell differentiation,  release  of  several  kinds  of  growth  factors  and  chemo-attractants  as  well  as increased cell migration. Besides  reduction  of  animal  experiments    and  cost-effectiveness,  the  biggest  advantage  of In-Vitro  Shock  Wave  Treatment  (IVSWT)  may  be  the  possibility  of  studying  the  specific behaviour of a certain cell type. In shock wave mediated tissue regeneration most likely all cells  of  the  treated  tissue  are  involved,  even  systemic  effects  are  discussed.  Nevertheless, each cell type plays a specific role and has its own intrinsic function.  IVSWT enables us to detect this particular functions and may thereby give us better understanding of the complex...

      LL37 and Shock Waves       antimicrobial peptides Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009;30(3):131-41.       antimicrobial peptides Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009;30(3):131-41. LL37 is an antimicrobial peptide which is released upon  mechanical stress. It builds complexes with RNA and can thus activate Toll-like receptors and mediate inflammation.       hypothesis LL37 is released upon SWT and complexes extracellular.       RNA levels are increased after SWT finding no. 1 RNA Nanodrop no vortex 141114 R N A  (n g /m l) CT R...

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(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria, 3 University Hospital for Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria,...

Abstract—Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation modulatory effects were described. However, the mechanism remains largely unknown. We hypothesized that SWT modulates inflammation via toll-like receptor 3 (TLR3) through the release of...

Aims Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for the treatment of ischaemic heart or lim disease. Despite promising results in preclinical and clinical trials, the exact mechanism of action remains unknown. Toll-like...

  Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that shock waves do cause a biological stimulus to target cells or tissue without any subsequent damage. Therefore, in vitro experiments are of increasing interest. Various...