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    • Non-Invasive Shockwave Therapy Improves Heart Muscle Function

    Non-Invasive Shockwave Therapy Improves Heart Muscle Function

    Title of study: Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves Authors: Leo Pölzl, Felix Nägele, Jakob Hirsch, Michael Graber, Daniela Lobenwein, Elke Kirchmair, Rosalie Huber, Christian Dorfmüller, Sophia Lechner, Georg Schäfer, Martin Hermann, Helga Fritsch,...
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    miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

    miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

    As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous repair mechanisms in ischaemic heart disease is of particular interest. Recently, exosomes carrying angiogenic miRNAs have been described to improve heart function. However, it remains...
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    Spark Wave® Therapy Improves Cardiac Function

    Spark Wave® Therapy Improves Cardiac Function

    Ischemic heart disease remains the leading cause of mortality (12.7%) worldwide, causing more than 7 million deaths per year. Native angiogenesis after infarction most often is not sufficient for appropriate supply of hibernating cardiomyocytes, leading to pathologic left ventricle (LV) remodeling...
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    Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

    Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

    Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It is currently accepted that the isolation, expansion and application of resident cardiac cells may hold therapeutic promise for the future. Recently, it has been demonstrated...
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    Therapeutic Potential of Exosomes in Cardiovascular Protection

    Therapeutic Potential of Exosomes in Cardiovascular Protection

    Title: Exosomes and Cardiovascular Protection Authors: Sean M. Davidson, Kaloyan Takov, Derek M. Yellon Summary: Exosomes, small lipid bilayer vesicles secreted by cells in the cardiovascular system, have shown immense potential in providing cardioprotective effects. These vesicles, despite their technical...
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    Heart Regeneration becomes Reality!

    Heart Regeneration becomes Reality!

    Regeneration of infarcted heart muscle remained a dream of modern medicine despite of comprehensive research on stem cell and gene therapy. Both technologies have not gained broad clinical use due to limited clinical results and significant side-effects including tumor formation....
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    Shockwave Therapy Helping Patients With Peripheral Artery Disease

    Shockwave Therapy Helping Patients With Peripheral Artery Disease

    CBS News Stephanie Stahl reports. (Video) Click here to view video.
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    ​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

    ​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

    The main aim of our research in this field is to regenerate infarcted myocardium, respectively the hibernating myocardium. We use LAD ligation models – chronic, acute and ischemia/ reperfusion – in different species. Besides regeneration we work on the induction...
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    Shockwave Therapy Of The Heart​

    Shockwave Therapy Of The Heart​

    Ischemic heart disease represents a collective term for a continuous disease pathophysiology, ranging from acute myocardial infarction to congestive and chronic heart failure. According to the World Health Organization (WHO) and its Global Burden of Disease study 2010 ischemic heart...
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    Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

    Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

    Enhancement of flap survival through extracorporeal shock wave treatment (ESWT) is a promising new technique; however, no attempt has been made to define the optimal time point and frequency of ESWT to optimize treatment with ESWT for ischemic indications. Click...
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    Noninvasive Shockwaves Improve Ischemia-Induced Heart Dysfunction

    Noninvasive Shockwaves Improve Ischemia-Induced Heart Dysfunction

    Title: Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo Authors: Takahiro Nishida, Hiroaki Shimokawa, Keiji Oi, Hideki Tatewaki, Toyokazu Uwatoku, Kohtaro Abe, Yasuharu Matsumoto, Noriyoshi Kajihara, Masataka Eto, Takehisa Matsuda, Hisataka Yasui, Akira Takeshita,...
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    Doubts over heart stem-cell therapy

    Doubts over heart stem-cell therapy

    The cells are then injected back into the patient, to help repair damaged tissue. Original claims that they differentiated into replacement cells have been rejected , and many clinicians now believe that the cells act by releasing molecules that cause...
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    Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

    Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

    (Alexandra Aicher, MD; Christopher Heeschen, MD; Ken-ichiro Sasaki, MD; Carmen Urbich, PhD; Andreas M. Zeiher, MD; Stefanie Dimmeler, PhD) – Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of...
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    Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

    Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

    (​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria, 3 University Hospital for Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria,...
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    Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

    Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

    Abstract—Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation modulatory effects were described. However, the mechanism remains largely unknown. We hypothesized that SWT modulates inflammation via toll-like receptor 3 (TLR3) through the release of...
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    Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

    Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

    Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3). The antimicrobial peptide LL37 gets released by mechanical stress and is known to form complexes with nucleic acids thus activating Toll-like receptors. We...
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    Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

    Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

    Background Mechanical stimulation of acute ischemic myocardium by shock wave therapy (SWT) is known to improve cardiac function by induction of angiogenesis. However, SWT in chronic heart failure is poorly understood. We aimed to study whether mechanical stimulation upon SWT improves heart function in...
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    Shockwave Therapy Reduces Calcification of Decellularized Aortic Xenografts in Mice

    Shockwave Therapy Reduces Calcification of Decellularized Aortic Xenografts in Mice

    Title of study: Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice Authors: Can Tepeköylü, Daniela Lobenwein, Stefan Blunder, Radoslaw Kozaryn, Marion Dietl, Paul Ritschl, Elisabeth J Pechriggl, Michael J F...
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    Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

    Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

    Aims Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for the treatment of ischaemic heart or lim disease. Despite promising results in preclinical and clinical trials, the exact mechanism of action remains unknown. Toll-like...
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    Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

    Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

    Shock waves have been shown to induce recruitment of intravenously injected endothelial progenitor cells to ischemic hind limbs in rats. We hypothesized that shock wave treatment as sole therapy would induce angiogenesis in this ischemia model and would lead to...
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    Boosting Cardiac Performance: Epicardial Shockwave Therapy in Ischaemic Models

    Boosting Cardiac Performance: Epicardial Shockwave Therapy in Ischaemic Models

    Title: Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease Authors: Johannes Holfeld, Daniel Zimpfer, Karin Albrecht-Schgoer, Alexander Stojadinovic, Patrick Paulus, Julia Dumfarth, Anita Thomas, Daniela Lobenwein, Can Tepeköylü, Raphael Rosenhek, Wolfgang Schaden, Rudolf Kirchmair,...
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