Shockwave Therapy Clinical Studies

Title of study: Biological Mechanism of Musculoskeletal Shockwaves Authors: Ching-Jen Wang, MD (The Department of Orthopedic Surgery Chang Gung Memorial Hospital at Kaohsiung Taiwan), Feng-Sheng Wang, PhD (Medical Research Chang Gung Memorial Hospital at Kaohsiung Taiwan) and Kuender D. Yang,...

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        MANUAL    IVSWT Water Bath V2.0    Standardized Model for   In-Vitro Shock Wave Treatment (IVSWT)                Manual: IVSWT Water Bath V2.0 1 Introduction  by Johannes Holfeld, MD Innsbruck Medical University, Austria, October 2010 The number of in-vitro experiments in shock wave science increases continuously. This fact reflects  how  important  basic  research  findings  on  the  cellular  and  sub-cellular  level  are  for the future progress of shock wave therapy. In some very emerging fields better mechanistic understandings may be prerequisite for translation into clinical use or will at least support the application of already well established indications. Today’s  knowledge  of  shock  wave  effects  on  cell  cultures  includes  the  increase  of proliferation,  alteration  of  cell  membrane  receptors,  increase  and  acceleration  of  cell differentiation,  release  of  several  kinds  of  growth  factors  and  chemo-attractants  as  well  as increased cell migration. Besides  reduction  of  animal  experiments    and  cost-effectiveness,  the  biggest  advantage  of In-Vitro  Shock  Wave  Treatment  (IVSWT)  may  be  the  possibility  of  studying  the  specific behaviour of a certain cell type. In shock wave mediated tissue regeneration most likely all cells  of  the  treated  tissue  are  involved,  even  systemic  effects  are  discussed.  Nevertheless, each cell type plays a specific role and has its own intrinsic function.  IVSWT enables us to detect this particular functions and may thereby give us better understanding of the complex...

      LL37 and Shock Waves       antimicrobial peptides Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009;30(3):131-41.       antimicrobial peptides Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009;30(3):131-41. LL37 is an antimicrobial peptide which is released upon  mechanical stress. It builds complexes with RNA and can thus activate Toll-like receptors and mediate inflammation.       hypothesis LL37 is released upon SWT and complexes extracellular.       RNA levels are increased after SWT finding no. 1 RNA Nanodrop no vortex 141114 R N A  (n g /m l) CT R...

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    Background aims As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for native Schwann cells for in vitro testing and/or reimplantation. Extracorporeal shockwave treatment (ESWT) is an emergent technology in the field of...

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria, 3 University Hospital for Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria,...

Abstract—Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation modulatory effects were described. However, the mechanism remains largely unknown. We hypothesized that SWT modulates inflammation via toll-like receptor 3 (TLR3) through the release of...

Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in ischemic tissue by modulation of early inflammatory response via Toll-like receptor (TLR)...

The current ‘‘gold standard’’ for treatment of chronic fracture nonunion in the metaphyseal-diaphyseal region of the fifth metatarsal is intramedullary screw fixation. Complications with this procedure, however, are not uncommon. Shock wave therapy can be an effective treatment for fracture...