Title: Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

Authors: Yi-Ling Chen, Kuan-Hung Chen, Tsung-Cheng Yin, Tien-Hung Huang, Chun-Man Yuen,  Sheng-Ying Chung, Pei-Hsun Sung, Meng-Shen Tong, Chih-Hung Chen, Hsueh-Wen Chang, Kun-Chen Lin, Sheung-Fat Ko, and Hon-Kan Yip

This study investigated the potential of extracorporeal shockwave (ECSW) therapy to protect the sciatic nerve from diabetes-induced neuropathy in mice. The results showed that ECSW therapy effectively prevented neuropathy associated with diabetes.

The study used diabetic mice and divided them into two groups: one receiving ECSW therapy and the other serving as a control. The mice in the ECSW group received four sessions of ECSW treatment at 3-week intervals. After two weeks, the mice were examined for various markers of neuropathy.

The results showed that the mice treated with ECSW had significantly lower levels of oxidative stress, inflammation, and apoptosis markers in their cells compared to the control group. Additionally, the mRNA expressions of inflammation and oxidative stress markers in the sciatic nerve were significantly reduced in the ECSW group. The cellular expressions and microscopic findings further supported the beneficial effects of ECSW therapy in protecting the sciatic nerve against neuropathy.

These findings suggest that ECSW therapy has the potential to effectively prevent and protect against diabetic neuropathy. By reducing oxidative stress, inflammation, and apoptosis, ECSW therapy can help preserve the health and function of the sciatic nerve in diabetes. Further research is needed to better understand the underlying mechanisms and optimize the use of ECSW therapy for diabetic neuropathy.

In conclusion, ECSW therapy shows promise as a non-invasive and effective approach to prevent and protect against neuropathy associated with diabetes. It has the potential to improve the quality of life for individuals with diabetes by preserving nerve health and function.

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